mother kissing infant

MaterniT 21 plus

Your patients deserve more, so you should expect more from an NIPT

Time, experience and confidence are valuable resources in any practice. MaterniT 21 PLUS performs in key areas that ensure your time is spent wisely, delivering fast, reliable, and effective prenatal screening results.

When your current NIPT is not enough, use MaterniT 21 PLUS, the most clinically complete NIPT solution.1-4

Labcorp has run over 1 million non-invasive prenatal tests (NIPT) since pioneering the technology in 2011, including more than 30,000 twins and more than 50,000 genome-wide tests;5 the depth of experience you should expect from an NIPT.

Now offering more screening options and flexibility than other NIPTs,1-4 including GENOME-Flex – the first NIPT high risk pathway – MaterniT 21 PLUS will deliver more value to your practice, and more service to your patients.

Each of the new features is designed to deliver a tangible positive benefit to you and your patients, while improving the service levels you should expect from an NIPT laboratory.

Mosaicism Ratio.

Mosaicism Ratio

Personalized information for
patients with positive NIPT results.

The new Mosaicism Ratio result, only available with MaterniT 21 PLUS (at no extra cost), helps differentiate between a positive result that is more likely to be a true positive, and one with an increased chance to be a false positive.10  

Learn more

MaterniT 21 PLUS Features

Professional societies like ACOG, ACMG, and SMFM endorse and/or recognize NIPT as a screening option for all pregnant women.

A new NIPT high risk pathway

Genome-Flex

The only clinically validated genome-wide NIPT, screens all 23 chromosome pairs, reporting aneuploidies, large deletions and duplications greater than 7 Mb in addition to select microdeletions

Learn more about Genome-Flex

 MaterniT® GENOMEMaterniT® 21 PlusOther NIPTs**
Trisomy 13, 18, 21
Yes
Yes
Yes
Fetal sex
Yes
Yes
Yes
Sex chromosome aneuploidies
Yes
Yes
Yes
Microdeletions
Yes
Yes
Yes
Trisomy 16, 22
Yes
Yes
 
GENOME-Flex high risk pathway
Yes
Yes
 
Genome-wide with subchromosomal CNVs
Yes
  

*Optional feature. **Panorama® Prenatal Screen3 by Natera, PreludeTM Prenatal Screen4 by Counsyl, InnatalTM Prenatal Screen5 by Progenity, Harmony® Prenatal Test5 by Roche

Clear results with PPV and FF

MaterniT 21 PLUS now features Positive Predictive Value (PPV) in addition to Fetal Fraction (FF) on all positive lab reports, and Positive / Negative reporting to help you reduce time spent interpreting complicated patient reports. MaterniT 21 PLUS also allows for EMR and online interface ordering and reporting.

Rapid results, earlier in pregnancy

Low non-reportable results & fewer patient redraws

Sample Report

MaterniT® 21 PLUS customizable screening options and capabilities

MaterniT 21 PLUS also offers choice with four panels: Core; Core + ESS (enhanced sequencing series); Core + SCA (sex chromosome aneuploidies); and Core + ESS + SCA. With choice in panels— and fetal sex optional— MaterniT 21 PLUS is the most flexible and customizable commercial NIPT available.

Compare versions in the table below.

 MaterniT 21 PLUS CoreMaterniT 21 PLUS + SCAMaterniT 21 PLUS + ESSMaterniT 21 PLUS + SCA + ESSGENOME-Flex (Add On)GENOME-Flex (Add On) Redraw
Fetal sex (optional)
Yes
Yes
Yes
Yes
Yes
Yes
Singleton Pregnancies (Only)
Yes
Yes
Yes
Yes
Yes
Yes
Twin & Multiple Pregnancies
Yes
 
Yes
   
Trisomy 21 (Down syndrome)
Yes
Yes
Yes
Yes
Yes
Yes
Trisomy 18 (Edwards syndrome)
Yes
Yes
Yes
Yes
Yes
Yes
Trisomy 13 (Patau syndrome)
Yes
Yes
Yes
Yes
Yes
Yes
SCA - SEX CHROMOSOME ANEUPLOIDIES (Singleton Pregnancies Only)
45,X (Turner syndrome) 
Yes
 
Yes
Yes
Yes
47,XXY (Klinefelter syndrome) 
Yes
 
Yes
Yes
Yes
47,XXX (Triple X syndrome) 
Yes
 
Yes
Yes
Yes
47,XYY (XYY syndrome) 
Yes
 
Yes
Yes
Yes
ENHANCED SEQUENCING SERIES (CLINICALLY RELEVANT MICRODELETIONS AND ANEUPLOIDIES)
22q (DiGeorge syndrome)  
Yes
Yes
Yes
Yes
5p (Cri-du-chat syndrome)  
Yes
Yes
Yes
Yes
1p36 deletion syndrome  
Yes
Yes
Yes
Yes
15q (Prader-Willi syndrome)  
Yes
Yes
Yes
Yes
15q (Angelman syndrome)  
Yes
Yes
Yes
Yes
11q (Jacobsen syndrome)  
Yes
Yes
Yes
Yes
8q (Langer-Giedion syndrome)  
Yes
Yes
Yes
Yes
4p (Wolf-Hirschhorn syndrome)  
Yes
Yes
Yes
Yes
Trisomy 16  
Yes
Yes
Yes
Yes
Trisomy 22  
Yes
Yes
Yes
Yes
MaterniT GENOME - GENOME-WIDE SCREENING
Genome-wide with subchromosomal CNVs    
Yes
Yes
TAT
Turn Around Time3-5 days3-5 days3-5 days3-5 days72 hours72 hours
SPECIMEN COLLECTION GESTATIONAL AGE - 9 WEEKS
9 Weeks Gestational Age
Yes
Yes
Yes
Yes
Yes
Yes
MaterniT specimen collection kit

MaterniT specimen collection kit

The MaterniT specimen collection kit features new branding for better kit identification and fewer components – including one 10 mL Streck tube instead of two – for improved ease of use.

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Additional Resources

References

  1. Illumina. https://www.illumina.com/clinical/illumina_clinical_laboratory/verifi-pr.... Accessed August 15, 2018.
  2. Natera. https://www.natera.com/panorama-test/clinical-information. Accessed August 15, 2018.
  3. Counsyl. https://www.counsyl.com/services/prelude/clinical-info. Accessed August 15, 2018.
  4. Progenity. https://progenity.com/tests/innatal. Accessed August 15, 2018.
  5. Harmony. https://www.harmonytestusa.com/healthcare-professionals/providing-harmony. Accessed August 15, 2018.
  6. Internal data
  7. Internal data
  8. Palomaki GE, Deciu C, Lambert-Messerlian GM, et al. DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study. Genet Med. 2011;13(11):913-920.
  9. Wardrop J, McCullough R, Boomer T, et al. Maternal weight – impact on noninvasive prenatal testing (NIPT). Clinical poster presented at ACMG annual meeting, Florida 2016.
  10. Rafalko et al. Impact of Mosaicism Ratio on positive predictive value of cfDNA screening. Prenatal Diagnosis, 2020.