A novel report of multigenerational chromosome 16 centric fission

Sidney VanDyke-Ries, MS, LCGC; Ellen Parker, MS, LCGC; Stephanie Kramer, MS, CGC; Judith Knops, PhD, FACMG; Armine Mendivil, BS; Labcorp Genetics and Women’s Health, Labcorp, Santa Fe, NM; University of Kansas Health System, Kansas City, KS

Centric fission occurs when a centromere separates, resulting in two new stable chromosomes. Examples of centric fission have been detailed in the literature across many species; however, cases reported in humans are limited. Here we document a multigenerational inheritance of 16p and 16q telocentric chromosomes derived from a centric fission