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BRCAssure

What is BRCA?

The BRCA1 and BRCA2 (breast cancer 1 and 2) genes are two genes found within everyone’s normal genetic material. When mutations, or gene alterations, are found within these genes, the mutations can cause an increased risk for several specific types of cancer, including breast cancer and ovarian cancer.1, 2 

BRCA mutations account for 5%–10% of all breast cancers,3 and can occur in both men and women of any ethnic or racial background. The estimated frequency of a BRCA mutation occurring in the general population is 1 in 400 to 1 in 5004.

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BRCAssure

Targeted Testing for Hereditary
Breast and Ovarian Cancer

Labcorp's BRCAssure is a genetic test for BRCA1 and BRCA2 mutations in individuals at increased risk for developing hereditary breast, ovarian, or other cancers based on their personal or family history.

Having this information can allow your physician to provide the appropriate additional screening and/or prevention options that could help reduce your risk of developing cancer.

The BRCAssure test requires only a sample of blood and filling out a family history questionnaire.

BRCAssure Panels

Risk of cancer in individuals with a BRCA1 or BRCA2 mutation4

Cancer TypeGeneral population (no mutation)Individuals with mutation
  BRCA1BRCA2
Breast12%46-87%38-84%
Ovarian1–2%39-63%16.5-27%
Male Breast0.1%1.2%Up to 8.9%
Prostate

6% through age 69

8.6% by age 65

15% by age 65; 20% lifetime

Pancreatic0.5%1–3%2–7%

Additional Resources

References

  1. BRCA1. Genetics Home Reference. Available at: http://ghr.nlm.nih.gov/gene/BRCA1. Accessed September 15, 2017.
  2. BRCA2. Genetics Home Reference. Available at: http://ghr.nlm.nih.gov/gene/BRCA2. Accessed September 15, 2017.
  3. BRCA1 and BRCA2: Cancer risk and genetic testing. National Cancer Institute website. Available at: http://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet. Accessed September 15, 2017.
  4. Petrucelli N, Daly MB and Pal T. BRCA1- and BRCA2-associated hereditary breast and ovarian cancer. Gene Reviews®. Available at: http://www.ncbi.nlm.nih.gov/books/NBK1247. Accessed February 2018.