generations of women

Hereditary Cancer Panels

VistaSeq®

Did you know as much as 10% of cancers are inherited?

When people review their family’s medical history, they may find a number of relatives who have had various types of cancer. This may be due to their relatives having certain risk factors in common, such as smoking, or it may be due to an inherited gene mutation that can increase their risk for developing cancer.1

An inherited mutation is one that is passed down from either your mother or father. Sometimes inherited mutations can cause a person to have an increased risk for certain types of cancer. In fact, five to ten percent of all cancers result directly from inherited mutations.1

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Focused Testing for Hereditary Cancer Syndromes

VistaSeq® is a portfolio of multi-gene tests that detects inherited mutations in genes that have been associated with an increased risk of developing hereditary cancers.

Having this information can allow your physician to provide the appropriate additional screening and/or prevention options that could help reduce your risk.

Test menu panels

VistaSeq Hereditary Cancer Tests by NGSTest CodeGenes
Hereditary Cancer - 27 multi-gene panel481220APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FAM175A, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PRKAR1A, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53.
Hereditary Cancer Panel without BRCA1/2 Genes481240APC, ATM, BARD1, BMPR1A, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FAM175A, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PRKAR1A, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53.
High/Moderate Risk Breast Cancer Panel481452ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, STK11, TP53
Breast Cancer Panel481319ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHECK2, FAM175A, MRE11A, MYTYG, NBN, NF1, PALB2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53
Breast and GYN Cancer Panel481341ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2,EPCAM, FAM175A, FANCC, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53
GYN Cancer Panel481330BRCA1, BRCA2, CHEK2, EPCAM, MHL1, MSH2, MSH6, MUTYH, PMS2, PTEN, TP53
Lynch Syndrome Panel483543MLH1, MSH2, MSH6, PMS2, EPCAM
MLH1 Comprehensive Analysis483496MLH1
MSH2 Comprehensive Analysis483508MSH2
MSH6 Comprehensive Analysis483520MSH6
PMS2 Comprehensive Analysis483532PMS2
High Risk Colorectal Cancer Panel481352APC, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2
Colorectal Cancer Panel481363APC, ATM, AXIN2, BLM, BMPR1A, BRCA1, BRCA2, CDH1, CDKN2A, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53
APC Comprehensive Analysis483484APC
Pancreatic Cancer Panel481385APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53, VHL
Prostate Cancer Panel483555ATM, BRCA1, BRCA2, CHEK2, HOXB13 (NGS only), MLH1, MSH2, MSH6, PALB2, PMS2
Endocrine Cancer Panel481374CDC73, MAX, MEN1, NF1, PRKAR1A, PTEN, RET, SDHB, SDHC, SDHD, TMEM127, TP53, VHL
MEN1 Comprehensive Analysis483460MEN1
RET Comprehensive Analysis483472RET
Brain / CNS / PNS Cancer Panel481386ALK, APC, MEN1, MLH1, MSH2, MSH6, NBN, NF1, NF2, PHOX2B, PTCH1, PMS2, RB1, SMARCB1, SUFU, TP53, VHL
Renal Cell Cancer Panel481407EPCAM, FH, FLCN, GPC3, MET, MITF (c.952G>A), MLH1, MSH2, MSH6, PTEN, PMS2, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL, WT1

Additional Resources

Reference:

  1. Family Cancer Syndromes. American Cancer Society. Available at www.cancer.org/cancer/cancercauses/geneticsandcancer/hereditary-andcancer, accessed May 6, 2015.