MaterniT® 21 plus
Your patients deserve more, so you should expect more from a NIPS (NIPT)
Time, experience and confidence are valuable resources in any practice. MaterniT 21 PLUS performs in key areas that ensure your time is spent wisely, delivering fast, reliable, and effective prenatal screening results.
Proven performance in twin pregnancies
Despite overall limited data on cell-free DNA (cfDNA) testing in twin gestations, MaterniT 21 PLUS has demonstrated high sensitivity and specificity in screening for trisomy 21 in twins from the first trimester of pregnancy (comparable to that observed in singleton pregnancies), as well as promising performance in screening for trisomies 13 and 18, according to the results of a newly published study.1
Access a clinical study on MaterniT 21 PLUS screening in twin pregnancies
Use MaterniT 21 PLUS, the most clinically complete cfDNA solution.2-6
Labcorp has run over 3 million noninvasive prenatal screening tests since pioneering the technology in 2011, including more than 60,000 twins and more than 135,000 genome-wide tests.7 With high sensitivity and specificity observed in both singleton and twin gestations in a newly published study1, MaterniT 21 PLUS provides timely, effective results to you and your patients.
MaterniT 21 PLUS has more screening options and flexibility than other cfDNA prenatal tests,2-6 including GENOME-Flex—the first cfDNA high risk pathway. Each of the features is designed to deliver more value to your practice, tangible positive benefit to your patients and overall higher service levels expected from a cfDNA laboratory.
Mosaicism Ratio
Personalized information for
patients with positive NIPS (NIPT) results.
The new Mosaicism Ratio result, only available with MaterniT 21 PLUS (at no extra cost), helps differentiate between a positive result that is more likely to be a true positive, and one with an increased chance to be a false positive.8
MaterniT 21 PLUS Features
A new NIPS (NIPT) high risk pathway
Genome-Flex
The only clinically validated genome-wide NIPS (NIPT), screens all 23 chromosome pairs, reporting aneuploidies, large deletions and duplications greater than 7 Mb in addition to select microdeletions
| MaterniT® GENOME | MaterniT® 21 Plus | Other NIPSs (NIPTs)** | |
|---|---|---|---|
| Trisomy 13, 18, 21 | Yes | Yes | Yes |
| Fetal sex* | Yes | Yes | Yes |
| Sex chromosome aneuploidies | Yes | Yes | Yes |
| Microdeletions | Yes | Yes | Yes |
| Trisomy 16, 22 | Yes | Yes | |
| GENOME-Flex high risk pathway | Yes | Yes | |
| Genome-wide with subchromosomal CNVs | Yes |
*Optional feature. **Panorama® Prenatal Screen3 by Natera, PreludeTM Prenatal Screen4 by Counsyl, InnatalTM Prenatal Screen5 by Progenity, Harmony® Prenatal Test6 by Roche
Clear results with PPV and FF
MaterniT 21 PLUS now features Positive Predictive Value (PPV) in addition to Fetal Fraction (FF) on all positive lab reports, and Positive / Negative reporting to help you reduce time spent interpreting complicated patient reports. MaterniT 21 PLUS also allows for EMR and online interface ordering and reporting.
Sample Report
MaterniT 21 PLUS customizable screening options and capabilities
- Choice of four panels: Core; Core + ESS (enhanced sequencing series); Core + SCA (sex chromosome aneuploidies); and Core + ESS + SCA
- Proven performance: MaterniT 21 PLUS has shown high sensitivity and specificity in screening for trisomies 13, 18 and 21 in singleton gestations, as well as for trisomy 21 in twin gestations (in a newly published study)1
With choice in panels—and fetal sex optional—MaterniT 21 PLUS is the most flexible and customizable commercial cfDNA test available across singleton pregnancies and twin pregnancies where applicable.
Compare versions in the table below.
| MaterniT 21 PLUS Core | MaterniT 21 PLUS + SCA | MaterniT 21 PLUS + ESS | MaterniT 21 PLUS + SCA + ESS | GENOME-Flex (Add On) | GENOME-Flex (Add On) Redraw | |
|---|---|---|---|---|---|---|
| Fetal sex (optional) | Yes | Yes | Yes | Yes | Yes | Yes |
| Singleton Pregnancies (Only) | Yes | Yes | Yes | Yes | Yes | Yes |
| Twin & Multiple Pregnancies | Yes | Yes | ||||
| Trisomy 21 (Down syndrome) | Yes | Yes | Yes | Yes | Yes | Yes |
| Trisomy 18 (Edwards syndrome) | Yes | Yes | Yes | Yes | Yes | Yes |
| Trisomy 13 (Patau syndrome) | Yes | Yes | Yes | Yes | Yes | Yes |
| SCA - SEX CHROMOSOME ANEUPLOIDIES (Singleton Pregnancies Only) | ||||||
| 45,X (Turner syndrome) | Yes | Yes | Yes | Yes | ||
| 47,XXY (Klinefelter syndrome) | Yes | Yes | Yes | Yes | ||
| 47,XXX (Triple X syndrome) | Yes | Yes | Yes | Yes | ||
| 47,XYY (XYY syndrome) | Yes | Yes | Yes | Yes | ||
| ENHANCED SEQUENCING SERIES (CLINICALLY RELEVANT MICRODELETIONS AND ANEUPLOIDIES) | ||||||
| 22q (DiGeorge syndrome) | Yes | Yes | Yes | Yes | ||
| 5p (Cri-du-chat syndrome) | Yes | Yes | Yes | Yes | ||
| 1p36 deletion syndrome | Yes | Yes | Yes | Yes | ||
| 15q (Prader-Willi syndrome) | Yes | Yes | Yes | Yes | ||
| 15q (Angelman syndrome) | Yes | Yes | Yes | Yes | ||
| 11q (Jacobsen syndrome) | Yes | Yes | Yes | Yes | ||
| 8q (Langer-Giedion syndrome) | Yes | Yes | Yes | Yes | ||
| 4p (Wolf-Hirschhorn syndrome) | Yes | Yes | Yes | Yes | ||
| Trisomy 16 | Yes | Yes | Yes | Yes | ||
| Trisomy 22 | Yes | Yes | Yes | Yes | ||
| MaterniT GENOME - GENOME-WIDE SCREENING | ||||||
| Genome-wide with subchromosomal CNVs | Yes | Yes | ||||
| TAT | ||||||
| Turn Around Time | 3-5 days | 3-5 days | 3-5 days | 3-5 days | 72 hours | 72 hours |
| SPECIMEN COLLECTION GESTATIONAL AGE - 9 WEEKS | ||||||
| 9 Weeks Gestational Age | Yes | Yes | Yes | Yes | Yes | Yes |
MaterniT specimen collection kit
Starting in July 2023, we are updating our MaterniT cfDNA specimen collection kits with a new look to help increase understanding that MaterniT is a screening test. The kit components and specimen collection requirements will not change.
Additional Resources
Understanding Costs
Use our cost estimator get an immediate estimate for most tests we offer based on your specific insurance plan (so have your policy number handy).
Understand Your Results
If you have already had a test, we can answer questions about your results.
Genetic Counseling
Genetic counselors translate and communicate genetic information into practical, understandable terms.
References
- Dugoff L, Koelper NC, Chasen ST, et al. Cell-free DNA screening for trisomy 21 in twin pregnancy: a large multicenter cohort study. Am. J. Obstet. Gynecol. 2023. doi:10.1016/j.ajog.2023.04.002.
- Illumina. https://www.illumina.com/clinical/illumina_clinical_laboratory/verifi-pr.... Accessed August 15, 2018.
- Natera. https://www.natera.com/panorama-test/clinical-information. Accessed August 15, 2018.
- Counsyl. https://www.counsyl.com/services/prelude/clinical-info. Accessed August 15, 2018.
- Progenity. https://progenity.com/tests/innatal. Accessed August 15, 2018.
- Harmony. https://www.harmonytestusa.com/healthcare-professionals/providing-harmony. Accessed August 15, 2018.
- Internal data
- Rafalko et al. Impact of Mosaicism Ratio on positive predictive value of cfDNA screening. Prenatal Diagnosis, 2020.