MaterniT 21 plus
Your patients deserve more, so you should expect more from a NIPS (NIPT)
Time, experience and confidence are valuable resources in any practice. MaterniT 21 PLUS performs in key areas that ensure your time is spent wisely, delivering fast, reliable, and effective prenatal screening results.
When your current NIPS (NIPT) is not enough, use MaterniT 21 PLUS, the most clinically complete NIPS (NIPT) solution.1-4
Labcorp has run over 1 million non-invasive prenatal screening (NIPS/NIPT) since pioneering the technology in 2011, including more than 30,000 twins and more than 50,000 genome-wide tests;5 the depth of experience you should expect from an NIPS (NIPT).
Now offering more screening options and flexibility than other NIPSs (NIPTs),1-4 including GENOME-Flex – the first NIPS (NIPT) high risk pathway – MaterniT 21 PLUS will deliver more value to your practice, and more service to your patients.
Each of the new features is designed to deliver a tangible positive benefit to you and your patients, while improving the service levels you should expect from an NIPS (NIPT) laboratory.
Mosaicism Ratio
Personalized information for
patients with positive NIPS (NIPT) results.
The new Mosaicism Ratio result, only available with MaterniT 21 PLUS (at no extra cost), helps differentiate between a positive result that is more likely to be a true positive, and one with an increased chance to be a false positive.10
MaterniT 21 PLUS Features
A new NIPS (NIPT) high risk pathway
Genome-Flex
The only clinically validated genome-wide NIPS (NIPT), screens all 23 chromosome pairs, reporting aneuploidies, large deletions and duplications greater than 7 Mb in addition to select microdeletions
| MaterniT® GENOME | MaterniT® 21 Plus | Other NIPSs (NIPTs)** | |
|---|---|---|---|
| Trisomy 13, 18, 21 | Yes | Yes | Yes |
| Fetal sex | Yes | Yes | Yes |
| Sex chromosome aneuploidies | Yes | Yes | Yes |
| Microdeletions | Yes | Yes | Yes |
| Trisomy 16, 22 | Yes | Yes | |
| GENOME-Flex high risk pathway | Yes | Yes | |
| Genome-wide with subchromosomal CNVs | Yes |
*Optional feature. **Panorama® Prenatal Screen3 by Natera, PreludeTM Prenatal Screen4 by Counsyl, InnatalTM Prenatal Screen5 by Progenity, Harmony® Prenatal Test5 by Roche
Clear results with PPV and FF
MaterniT 21 PLUS now features Positive Predictive Value (PPV) in addition to Fetal Fraction (FF) on all positive lab reports, and Positive / Negative reporting to help you reduce time spent interpreting complicated patient reports. MaterniT 21 PLUS also allows for EMR and online interface ordering and reporting.
Sample Report
MaterniT® 21 PLUS customizable screening options and capabilities
MaterniT 21 PLUS also offers choice with four panels: Core; Core + ESS (enhanced sequencing series); Core + SCA (sex chromosome aneuploidies); and Core + ESS + SCA. With choice in panels— and fetal sex optional— MaterniT 21 PLUS is the most flexible and customizable commercial NIPS (NIPT) available.
Compare versions in the table below.
| MaterniT 21 PLUS Core | MaterniT 21 PLUS + SCA | MaterniT 21 PLUS + ESS | MaterniT 21 PLUS + SCA + ESS | GENOME-Flex (Add On) | GENOME-Flex (Add On) Redraw | |
|---|---|---|---|---|---|---|
| Fetal sex (optional) | Yes | Yes | Yes | Yes | Yes | Yes |
| Singleton Pregnancies (Only) | Yes | Yes | Yes | Yes | Yes | Yes |
| Twin & Multiple Pregnancies | Yes | Yes | ||||
| Trisomy 21 (Down syndrome) | Yes | Yes | Yes | Yes | Yes | Yes |
| Trisomy 18 (Edwards syndrome) | Yes | Yes | Yes | Yes | Yes | Yes |
| Trisomy 13 (Patau syndrome) | Yes | Yes | Yes | Yes | Yes | Yes |
| SCA - SEX CHROMOSOME ANEUPLOIDIES (Singleton Pregnancies Only) | ||||||
| 45,X (Turner syndrome) | Yes | Yes | Yes | Yes | ||
| 47,XXY (Klinefelter syndrome) | Yes | Yes | Yes | Yes | ||
| 47,XXX (Triple X syndrome) | Yes | Yes | Yes | Yes | ||
| 47,XYY (XYY syndrome) | Yes | Yes | Yes | Yes | ||
| ENHANCED SEQUENCING SERIES (CLINICALLY RELEVANT MICRODELETIONS AND ANEUPLOIDIES) | ||||||
| 22q (DiGeorge syndrome) | Yes | Yes | Yes | Yes | ||
| 5p (Cri-du-chat syndrome) | Yes | Yes | Yes | Yes | ||
| 1p36 deletion syndrome | Yes | Yes | Yes | Yes | ||
| 15q (Prader-Willi syndrome) | Yes | Yes | Yes | Yes | ||
| 15q (Angelman syndrome) | Yes | Yes | Yes | Yes | ||
| 11q (Jacobsen syndrome) | Yes | Yes | Yes | Yes | ||
| 8q (Langer-Giedion syndrome) | Yes | Yes | Yes | Yes | ||
| 4p (Wolf-Hirschhorn syndrome) | Yes | Yes | Yes | Yes | ||
| Trisomy 16 | Yes | Yes | Yes | Yes | ||
| Trisomy 22 | Yes | Yes | Yes | Yes | ||
| MaterniT GENOME - GENOME-WIDE SCREENING | ||||||
| Genome-wide with subchromosomal CNVs | Yes | Yes | ||||
| TAT | ||||||
| Turn Around Time | 3-5 days | 3-5 days | 3-5 days | 3-5 days | 72 hours | 72 hours |
| SPECIMEN COLLECTION GESTATIONAL AGE - 9 WEEKS | ||||||
| 9 Weeks Gestational Age | Yes | Yes | Yes | Yes | Yes | Yes |
MaterniT specimen collection kit
The MaterniT specimen collection kit features new branding for better kit identification and fewer components – including one 10 mL Streck tube instead of two – for improved ease of use.
Additional Resources
Understanding Costs
Use our cost estimator get an immediate estimate for most tests we offer based on your specific insurance plan (so have your policy number handy).
Understand Your Results
If you have already had a test, we can answer questions about your results.
Genetic Counseling
Genetic counselors translate and communicate genetic information into practical, understandable terms.
References
- Illumina. https://www.illumina.com/clinical/illumina_clinical_laboratory/verifi-pr.... Accessed August 15, 2018.
- Natera. https://www.natera.com/panorama-test/clinical-information. Accessed August 15, 2018.
- Counsyl. https://www.counsyl.com/services/prelude/clinical-info. Accessed August 15, 2018.
- Progenity. https://progenity.com/tests/innatal. Accessed August 15, 2018.
- Harmony. https://www.harmonytestusa.com/healthcare-professionals/providing-harmony. Accessed August 15, 2018.
- Internal data
- Internal data
- Palomaki GE, Deciu C, Lambert-Messerlian GM, et al. DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study. Genet Med. 2011;13(11):913-920.
- Wardrop J, McCullough R, Boomer T, et al. Maternal weight – impact on noninvasive prenatal testing (NIPT). Clinical poster presented at ACMG annual meeting, Florida 2016.
- Rafalko et al. Impact of Mosaicism Ratio on positive predictive value of cfDNA screening. Prenatal Diagnosis, 2020.