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Your patients deserve more, so you should expect more from an NIPT


Your patients deserve more, so you should expect more from an NIPT

Mosaicism ratio

Mosaicism Ratio. Personalized information for patients with positive NIPT results.

The new Mosaicism Ratio result, only available with MaterniT 21 PLUS (at no extra cost), helps differentiate between a positive result that is more likely to be a true positive, and one with an increased chance to be a false positive.10  

Maternit Genome Icon

When your current NIPT is not enough, use MaterniT 21 PLUS, the most clinically complete NIPT solution.1-4

Time, experience and confidence are valuable resources in any practice. MaterniT 21 PLUS performs in key areas that ensure your time is spent wisely, delivering fast, reliable, and effective prenatal screening results.

Integrated Genetics has run over 1 million non-invasive prenatal tests (NIPT) since pioneering the technology in 2011, including more than 30,000 twins and more than 50,000 genome-wide tests;5 the depth of experience you should expect from an NIPT.

Now offering more screening options and flexibility than other NIPTs,1-4 including GENOME-Flex – the first NIPT high risk pathway – MaterniT 21 PLUS will deliver more value to your practice, and more service to your patients.

Each of the new features is designed to deliver a tangible positive benefit to you and your patients, while improving the service levels you should expect from an NIPT laboratory.

Maternit 21 Plus - New Features

Genome-Flex: the first NIPT high risk pathwayGenome-Flex: the first NIPT high risk pathway
Clear results with PPV and FFClear results with PPV and FF

Clear results with PPV and FFClear results with PPV and FF

MaterniT 21 PLUS now features Positive Predictive Value (PPV) in addition to Fetal Fraction (FF) on all positive lab reports, and Positive / Negative reporting to help you reduce time spent interpreting complicated patient reports. MaterniT 21 PLUS also allows for EMR and online interface ordering and reporting.

Click here to view a sample MaterniT 21 PLUS report.


Patient Engagement ProgramPatient Engagement Program

Patient Engagement Program Genetics IconGenetics is complex; understanding pricing options doesn’t need to be

We work directly with your patients to make our pricing options transparent

With our new Patient Engagement Program, your choice of a genetic testing partner is clear

New cost estimator plus rapid, proactive support from our expert Every Mom Pledge team

Patient responsibility was $0 for over 74% of patients6

New program provides $299 price for MaterniT® 21 PLUS, informaSeq® and Inheritest® NGS for qualifying patients

Send your patients to or call 844.799.3243

SOCIETY GUIDELINES Professional societies like ACOG, ACMG, and SMFM endorse and/or recognize NIPT as a screening option for all pregnant women
MaterniT® GENOME MaterniT® 21 Plus Other NIPTs**
Trisomy 13, 18, 21
Fetal sex
Sex chromosome aneuploidies
Trisomy 16, 22
GENOME-Flex high risk pathway
Genome-wide with subchromosomal CNVs

*Optional feature. **Panorama® Prenatal Screen3 by Natera, PreludeTM Prenatal Screen4 by Counsyl, InnatalTM Prenatal Screen5 by Progenity, Harmony® Prenatal Test5 by Roche

30 years callout

MaterniT® 21 PLUS customizable screening options and capabilities

MaterniT 21 PLUS also offers choice with four panels: Core; Core + ESS (enhanced sequencing series); Core + SCA (sex chromosome aneuploidies); and Core + ESS + SCA. With choice in panels— and fetal sex optional— MaterniT 21 PLUS is the most flexible and customizable commercial NIPT available.

Compare versions in the table below.

MaterniT 21 PLUS Core MaterniT 21 PLUS + SCA MaterniT 21 PLUS + ESS MaterniT 21 PLUS + SCA + ESS GENOME-Flex (Add On) GENOME-Flex (Add On) Redraw
Fetal sex (optional)
Singleton Pregnancies (Only)
Twin & Multiple Pregnancies
Trisomy 21 (Down syndrome)
Trisomy 18 (Edwards syndrome)
Trisomy 13 (Patau syndrome)
SCA - SEX CHROMOSOME ANEUPLOIDIES (Singleton Pregnancies Only)
45,X (Turner syndrome)
47,XXY (Klinefelter syndrome)
47,XXX (Triple X syndrome)
47,XYY (XYY syndrome)
22q (DiGeorge syndrome)
5p (Cri-du-chat syndrome)
1p36 deletion syndrome
15q (Prader-Willi syndrome)
15q (Angelman syndrome)
11q (Jacobsen syndrome)
8q (Langer-Giedion syndrome)
4p (Wolf-Hirschhorn syndrome)
Trisomy 16
Trisomy 22
Genome-wide with subchromosomal CNVs
Turn Around Time 3-5 days 3-5 days 3-5 days 3-5 days 72 hours 72 hours
9 Weeks Gestational Age
MaternIT Kit

MaterniT specimen collection kit

The MaterniT specimen collection kit features new branding for better kit identification and fewer components – including one 10 mL Streck tube instead of two – for improved ease of use.

If you’ve not had a test and have questions about costs or coverage, use our estimator.

If you have already had a test performed, we can help answer questions about results.

Ask questions about genetic testing options or results, or schedule an appointment.


  1. Illumina. Accessed August 15, 2018.
  2. Natera. Accessed August 15, 2018.
  3. Counsyl. Accessed August 15, 2018.
  4. Progenity. Accessed August 15, 2018.
  5. Harmony. Accessed August 15, 2018.
  6. Internal data
  7. Internal data
  8. Palomaki GE, Deciu C, Lambert-Messerlian GM, et al. DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study. Genet Med. 2011;13(11):913-920.
  9. Wardrop J, McCullough R, Boomer T, et al. Maternal weight – impact on noninvasive prenatal testing (NIPT). Clinical poster presented at ACMG annual meeting, Florida 2016.
  10. Rafalko et al. Impact of Mosaicism Ratio on positive predictive value of cfDNA screening. Prenatal Diagnosis, 2020.