Adenosine deaminase (ADA) deficiency

Adenosine deaminase (ADA) deficiency is an inherited disease characterized by repeated, persistent, and potentially life-threatening infections. Symptoms are due to a defect in the production of an enzyme called adenosine deaminase. Without normal levels of this enzyme, toxic chemicals build up within the immune system leading to severe immunodeficiency, a state in which the body’s ability to fight infectious disease is absent or severely compromised. The severe form of ADA deficiency is also known as ADA-deficient severe combined immunodeficiency (SCID). View testing options