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Glycine encephalopathy (GCE) is an inherited disease that in its typical form is characterized by seizures in infancy and other progressive nervous system problems. It is caused by an abnormally low level of an enzyme that helps to break down the amino acid glycine, which is important in brain function. Symptoms are due to a toxic build-up of glycine in the body. Glycine encephalopathy is also known as non-ketotic hyperglycinemia (NKH). View testing options