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Print CPT 85660. If reflex testing is performed, concomitant CPT codes/charges will apply.
Synonyms
- Hb Solubility
- Sickle Cell Preparation
- Sickle Cell Solubility Test
- Sickle Cell Test
- Sickle Prep
- Sickledex™
Test Details
Turnaround Time
2 - 3 days
Use
Qualitative determination of presence of hemoglobin S; detect sickling hemoglobins; evaluate hemolytic anemia, undiagnosed hereditary anemia with morphologic (sickle-like) abnormalities on peripheral blood smear
Test Includes
Hemoglobin (Hb) solubility and automatic reflex to hemoglobin (Hb) fractionation blood (at additional charge), if positive.
Limitations
Methodology
Sodium hydrosulfite reduction
References
Chehab FF, Kan YW. Detection of sickle cell anaemia mutation by colour DNA amplification. Lancet. 1990 Jan 6; 335(8680):15-17. 1967329
Miale JB. Laboratory Medicine: Hematology. 6th ed. St Louis, Mo: Mosby-Year Book Inc;1982:624-625.
Additional Information
Specimen Requirements
Information on collection, storage, and volume
Specimen
Whole blood
Volume
1 mL
Minimum Volume
0.6 mL (Note: This volume does not allow for repeat testing.)
Container
Lavender-top (EDTA) tube; capillary puncture: three microhematocrit tubes
Note: Because this profile reflexes to Hemoglobinopathy Fractionation Cascade [121690] when positive, only a Lavender-top (EDTA) tube is allowed.
Storage Instructions
Room temperature
Causes for Rejection
Specimen other than whole blood received; clotted specimen
Collection
To avoid delays in turnaround time, please submit a separate lavender-top tube for each test requiring a lavender-top.