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Print CPT Contact CPT coding department at 800-222-7566, ext 6-8400.
Synonyms
- Long-term Culture, Fibroblast Karyotype Study
- Placental Tissue Chromosome Analysis
- Spontaneous Abortion Chromosome Analysis
- Tissue Karyotype
Test Details
Turnaround Time
11 - 16 days
Use
This test is used to evaluate possible chromosomal abnormalities as the cause of miscarriage, as well as an extended study of mosaicism found in blood chromosome analysis.
Special Instructions
Please include clinical information, previous cytogenetic report or karyotype.
If prior Cell-free DNA/NIPT studies have been performed, include copy of the report.
Call 800-345-4363 if there are any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825].
Test Includes
20 Metaphases counted per study; 2 to 3 banded karyotypes per study
Limitations
Some products of conception may only contain maternal tissue.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Tissue culture following enzymatic digestion of tissue. Standard harvesting and G-banding procedures are used with 20 metaphases examined and two karyotypes prepared.
Specimen Requirements
Information on collection, storage, and volume
Specimen
Tissue, skin, products of conception, placental biopsy
Volume
2 to 4 mm³
Container
Submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' balanced salt solution or Labcorp transport medium. The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. Saline is not recommended for transport. Do not use urine containers for shipping.
Storage Instructions
Refrigerate. Do not freeze.
Causes for Rejection
Upon receipt, suitability of specimen will be determined by the Cytogenetics laboratory.
Collection
Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. This is especially true in stillborn cases in which both cord blood and tissue samples are often not viable. If specimen is a product of conception, submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport media. Gross contamination, necrotic tissue and specimen in fix cannot be processed.