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Print CPT Contact CPT coding department at 800-222-7566, ext 6-8400.
Synonyms
- Long-term Culture, Fibroblast Karyotype Study
- Placental Tissue Chromosome Analysis
- Spontaneous Abortion Chromosome Analysis
- Tissue Karyotype
Test Details
Turnaround Time
11 - 16 days
Use
Evaluate possible chromosomal abnormalities as the cause of miscarriage. Extended study of mosaicism found in blood chromosome analysis.
Special Instructions
Please include clinical information, previous cytogenetic report, or karyotype.
If prior NIPT studies have been performed, include copy of the report.
Call 800-345-4363, if there any any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825].
Test Includes
20 Metaphases counted per study; 2 to 3 banded karyotypes per study
Limitations
Some products of conception may only contain maternal tissue.
Methodology
Tissue culture following enzymatic digestion of tissue. Standard harvesting and G-banding procedures are used with 20 metaphases examined and two karyotypes prepared.
Specimen Requirements
Information on collection, storage, and volume
Specimen
Tissue, skin, products of conception, placental biopsy
Volume
2 to 4 mm³
Container
Sterile container with sterile Ringer's lactate or Hanks' balanced salt solution or transport medium provided by the cytogenetics laboratory. Do not use urine containers for shipping.
Storage Instructions
Refrigerate. Do not freeze.
Causes for Rejection
Gross contamination; necrotic tissue; specimen in fixative
Collection
Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. This is especially true in stillborn cases in which both cord blood and tissue samples are often not viable. If specimen is a product of conception, submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution, or LabCorp transport medium.