144011 Sexually Transmitted Infections (STI) Profile

Test Details

Turnaround Time

1 - 4 days

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Use

Screen for and diagnose sexually transmitted infections and blood borne pathogens including syphilis, hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV. Testing aligns with current guidelines and recommendations.

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

If reflex test is performed, additional charges/CPT code(s) may apply.

HIV p24 Antigen/Antibody With Reflex to Confirmation [083935] requires a dedicated, unopened, gel-barrier tube or red-top tube sent directly to the testing facility.

Test Includes

RPR with reflex to quantitative RPR and confirmatory Treponema pallidum antibodies; HIV p24 Antigen/Antibody with reflex to confirmation; HBV screening and diagnosis (HBsAg, anti-HBs, HBc-total with reflex to IgM); HCV antibody with reflex to quantitative real-time PCR. If reflex testing is performed, additional charges/CPT code(s) may apply.

Limitations

Some of the assays in this panel have not been FDA cleared or approved for the screening of blood or plasma donors, nor have assay performance characteristics been established for immunocompromised or immunosuppressed patients, cord blood, or patients less than 2 years of age.

Methodology

See individual test components.

References

AAP Committee on Fetus and Newborn and ACOG Committee on Obstetric Practice. Guidelines for Perinatal Care. Kilpatrick SJ, Papile LA, Macones GA, eds. 8th edition, September 2017.

Centers for Disease Control and Prevention (CDC). Hepatitis B. CDC website: www.cdc.gov/hepatitis/hbv/index.htm. Accessed March 2022.

Centers for Disease Control and Prevention (CDC), The American College of Obstetrics and Gynecologists. Screening and Referral Algorithm for Hepatitis B Virus (HBV) Infection Among Pregnant Women. CDC website: https://www.cdc.gov/hepatitis/hbv/pdfs/prenatalhbsagtesting_508.pdf. Accessed March 2022.

Schillie S, Vellozzi C, Reingold A, et al. Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2018; 67(1):1-31.29939980

U.S. Department of Health and Human Service. 2020. Sexually Transmitted Infections: National Strategic Plan for the United States 2021-2025. Washington, DC. Accessed March 2022 at https://www.hhs.gov/sites/default/files/STI-National-Strategic-Plan-2021-2025.pdf.

U.S. Preventive Services Task Force: Screening for Hepatitis B Virus Infection in Pregnant Women: Recommendation Statement. Am Fam Physician. 2020 Jan 15;101(2):112-114.31939639