Cytogenetics Products of Conception (POC) Chromosome Analysis

CPT 88233; 88262
Synonyms Karyotype

Test Details

Turnaround Time

11 - 16 days Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.


Rule out chromosome abnormalities as a cause of miscarriage; determine fetal karyotype

Special Instructions

Preferred Specimen Types: Placenta – Tissue that contains chorionic villi (has 90% success rate) Umbilical Cord Skin – Take biopsy from under the arm or inner thigh. Avoid muscle, tendons or tough skin (such as heel). Sample size should be 3 mm minimum. Internal Organs – Liver, lung, kidney, thymus (have a 20% success rate) Whole Fetus – Please take a biopsy. Whole fetus samples are not accepted. Unacceptable Specimens – Specimens that have been fixed. We will not be able to culture cells as fixatives kill the cells. Common types of fixatives are formalin, formaldehyde and alcohol. Frozen specimens will not be able to be cultured as freezing kills the cells. If prior NIPT or maternal serum screening studies have been performed, include copy of report.

Specimen Requirements

Information on collection, storage, and volume


Products of conception (POC)


3-4 mm POC specimen or 50-100 mg of each tissue; if possible, always include chorionic villi


Laboratory-provided screw-top tubes with sterile transport medium

Storage Instructions

Refrigerate. Do not freeze.

Causes for Rejection

Gross contamination; frozen tissue; specimen in fixative


Obtain POC’s using a sterile technique. Snip tissue using sterile scissors, etc. Cover specimen with sterile gauze to prevent contamination from airborne bacteria. POC’s often contain large numbers of bacteria, so for a short period it is fine to keep the specimen at room temperature. For overnight or longer, it is better to place the specimen in the refrigerator to keep the bacteria from overgrowing the specimen. In the absence of Integrated Genetics tubes, use any sterile screw-top container with tissue culture medium, Hanks Balanced Salt Solution or Earls and add antibiotics: Penicillin/Streptomycin (100 IU/ml/100 μg/ml) or Gentamycin (50 μg/ml). If the Integrated Genetics media has expired, please ship the specimen in the expired media, as it is preferable to any other types of tissue culture media. Do not place in formalin.